The overall objective of our research program is to determine whether glycan biosynthesis is an early step in enabling RTC adaptation and a selective vulnerability during cancer progression that can be targeted to prevent recurrence. Using complex disease modeling, together with functional genomics, single-cell approaches, and biochemical tools to characterize GAGs, our research will address the following biological questions:
Project 1: Do GAGs promote MRD activation of endochondral ossification?
Project 2: How do GAGs regulate the MRD-recurrence continuum?
Project 3: How do GAGs synthesized by MRD regulate the innate immune system?
Project 2: How do GAGs regulate the MRD-recurrence continuum?
Project 3: How do GAGs synthesized by MRD regulate the innate immune system?